Objective: The purpose of the present study was to investigate mediating role of spiritual intelligence in relationship between career path adaptability with entrepreneurial intention in secondary school students. Method: This was descriptive-correlation research. The statistical population of the study was secondary school students who of Qom city in year academic 2023-2024. The sample size was selected based on Klein's model (2023) and with multistage random cluster sampling of 500 studtns. Data collection tools include the self-report entrepreneurship intention questionnaire (EIQ) of Linan and Chen (2009), career adapt-abilities scale (SAAS) of Savickas and Porfeli (2012) and spiritual intelligence self-report inventory (SISRI-24) of King (2008). Data were analyzed using Pearson correlation and structural equations modeling. Findings: The results showed direct effect of career path adaptability (β= 0.64 and sig=0.001) on entrepreneurial intention are significant. The results also showed that spiritual intelligence has a significant mediating role in the relationship between career path adaptability (β = 0.68 and sig = 0.001) with entrepreneurial intention. Also, the final research model had a good fit (RMSEA=0.06, SRMR=0.03, p<0.05) and 73% of the variance of entrepreneurial intention is explained. Conclusion: According to the findings of this research and the role of career path adaptability and spiritual intelligence in entrepreneurial intention in students, it is suggested that the results of this study be used to increase entrepreneurial intention in secondary school students