Aim: The purpose of the research was to model the structural relationships of faculty members' innovation ability based on academic boundary spanning with the mediation of job crafting. Methods: The research method was sequential mixed-exploratory (qualitative-quantitative). The research population was 2189 faculty members of public universities in Tehran in 1402, which was determined by Cochran's formula to the number of 327 people, and sampling was done using stratified random sampling. The data were collected using the researcher-made questionnaire of the academic boundary spanning, the innovation ability, and the job crafting. Data analysis was done with Pearson correlation test and structural equation modeling technique. Results: The findings showed that boundary spanning has a positive and significant effect on innovation ability (0.344) and job crafting by 0.388, boundary spanning has a positive and significant effect by 0.425 on job crafting. Also, the indirect effect of boundary spanning on innovation ability through job crafting is 0.165. Conclusion: The final result of the research is that in order to improve the ability of faculty members to innovate, the development of boundary spanning should be given the attention of university managers and job crafting should be given the attention of faculty members.